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UC Davis Study Reports That Warmblood Fragile Foal Syndrome is Not Associated with Catastrophic Breakdown in Thoroughbreds
The UC Davis Veterinary Genetics Laboratory offers the WFFS genetic test and recommends testing for all Warmblood breeds since the carrier rate in Warmbloods is estimated to be around 9-11 percent. Since the allele was found to be present in the Thoroughbred population, albeit at a low frequency, genetic testing could eliminate the possibility of breeding two carriers with the potential of producing an affected offspring.
Bellone, R. , Ocampo, N. , Hughes, S. , Le, V. , Arthur, R. , Finno, C. and Penedo, M. (2019), Warmblood fragile foal syndrome type 1 mutation (PLOD1 c.2032G>A) is not associated with catastrophic breakdown and has a low allele frequency in the Thoroughbred breed. Equine Vet J. Accepted Author Manuscript. doi:10.1111/evj.13182. https://onlinelibrary.wiley.com/doi/abs/10.1111/evj.13182?af=R.
Additional information about WFFS genetic testing is available through the UC Davis Veterinary Genetics Laboratory: https://www.vgl.ucdavis.edu/services/horse/WFFS.php.
UC Davis School of Veterinary Medicine, Statement regarding the Warmblood Fragile Foal mutation in Thoroughbreds, April 5, 2019: https://www.vetmed.ucdavis.edu/news/statement-regarding-warmblood-fragile-foal-mutation-thoroughbreds
UC Davis Center for Equine Health, Equine Health Topics database, Warmblood Fragile Foal Syndrome: https://ceh.vetmed.ucdavis.edu/health-topics/warmblood-fragile-foal-syndrome-type-1-wffs
Contact: Dr. Rebecca Bellone, Director, UC Davis Veterinary Genetics Laboratory, firstname.lastname@example.org, (530) 752-9299
About the UC Davis Center for Equine Health
As part of the UC Davis School of Veterinary Medicine, the Center for Equine Health is dedicated to advancing the health, welfare, performance and veterinary care of horses through research, education and public service. We accomplish this by providing academic leadership and by serving as the organizational umbrella under which equine research is funded and conducted at the UC Davis School of Veterinary Medicine. We bring together research facilities, students, veterinary residents, researchers, and veterinarians to tackle important problems affecting horse health. For more information about the Center for Equine Health, please visit https://ceh.vetmed.ucdavis.edu/.